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Dipyridamole has a vasodilatory outcome. Upper body pain could be precipitated or aggravated in individuals with underlying coronary artery disease who're getting dipyridamole.
In case of intolerable complications during Original therapy, swap to 1 capsule at bedtime and lower-dose aspirin in the morning; resume BID dosing inside one week (2.1)
Salicylate can inhibit renal clearance of methotrexate, bringing about bone marrow toxicity, particularly in the aged or renal impaired.
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The very best dose administered in these research (seventy five mg/kg/day) was, with a mg/m2 basis, about reminiscent of the most encouraged everyday human oral dose (MRHD) in mice and about twice the MRHD in rats.
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